The way we do science is changing dramatically. The future will show that we cannot ignore the confluence of different sciences, and of the latter with technology and human factors as we know them today. Otherwise, we will probably compromise the future accuracy and/or the relevance of the results of classical sciences, and thus, of their ultimate goal: acquiring knowledge. Not knowing how to take all these challenges into account should no longer be an excuse for not trying. We present some modest conjectures and some practical evidence from research in Informatics, a TechnoScience where the confluence of Computing Science, Computer Technology, and Humans, has incubated a natural field for thought experiments along the lines just proposed. In our talk, we digress through themes as diverse as causal and temporal ordering, feedback, ambient intelligence, sentient objects, observation error and coverage of hypothesis, computer crashes and Byzantine failures, determinism and probabilities, uncertainty versus predictability, pervasive computing and pervasive hacking, malicious intelligence.